Abstract

The data presented suggest that the intravenous or intraperitoneal administration of bis(2‐ethylhexyl) phthalate prolongs hexobarbital sleep time in mice and rats by enlarging the lipophilic pool, a phenomenon that can be replicated by pretreatment of the animals with olive oil. These results call attention to the importance of considering the physical characteristics of a substance when evaluating its effect on a pharmacologically active agent.

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