Abstract
Despite intense scrutiny, the signals that determine whether a given RNA is degraded by the highly conserved and selective nonsense‐mediated RNA decay (NMD) pathway remain murky. In this issue of The EMBO Journal , Kishor et al shed light on this issue by demonstrating that the RNA‐binding protein, hnRNP L, protects a subset of RNAs from degradation by NMD. This mechanism is responsible for stabilizing the mRNA encoding the pro‐survival “oncogenic” protein, BCL‐2, in B‐cell lymphoma.
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