Abstract
ABSTRACT We have studied the pulmonary effects of nitrogen dioxide exposure in rats using a series of biochemical parameters, including lung weight, protein and DNA contents, oxygen consumption, glucose metabolism, sulfhydryl metabolism, and the activities of various marker enzymes. To date, the exposure has included nitrogen dioxide concentrations between 3 and 7 ppm (5640 and 13160 ug/m 3 ) for periods of up to 7 days. The enzymatic activitiesjn the lung showed a general increase after exposure to 7 ppm (13160 ug/m 3 nitrogen dioxide. After exposure to 3 ppm (5640 ug/m 3 ) nitrogen dioxide these activities showed only a trend of nonsignificant increase. However, if the animals were made deficient in dietary vitamin E, an exposure to 3 ppm (5640 ug/m 3 ) nitrogen dioxide produced a significant increase in biochemical parameters measured. These increases might signify a repair of lung tissue injured by nitrogen dioxide, and that the injurious effects could be modulated by altering dietary antioxidant nutrient.
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