Abstract
BackgroundMicro-RNA (miRNA) is one of the non-coding RNAs that exist in human genome. miRNAs play an important role in the expression of target genes. Several studies have indicated that organization of human genome is not random. In order to investigate the distribution of miRNAs on human chromosomes, the present study was carried out.ResultsUsing the data from miRBase database, we found 1913 loci coding for miRNAs (MIRs). Human chromosome bands 1p36, 1q22, 1q24, 2q13, 2q35, 3p21, 6p21, 7q22, 8p23, 8q24, 9q22, 9q34, 11q12-q13, 12q13, 14q32, 16p13, 16q24, 17p13, 17q11, 17q21, 17q25, 19p13, 19q13, 20q13, 21p11, 22q13, and Xq26-q28 were significantly bearing higher number of MIRs. The 14q32 and 19q13 with 4.11 and 3.59 MIRs per mega-base pair, respectively, were the most MIR-richest human chromosomal bands. The number of MIRs on chromosomal bands significantly decreased as a function of distance from telomere (r = − 0.949, df = 5, P = 0.001).ConclusionsOur current data suggest that MIRs are not randomly distributed on human genomes.
Highlights
Micro-RNA is one of the non-coding RNAs that exist in human genome. miRNAs play an important role in the expression of target genes
Based on human chromosomal distribution of 186 MIRs, it has been reported that the majority of MIRs are located in cancer-associated genomic regions or at fragile sites, indicating the non-random distribution of MIRs [26]
We investigated the distribution of large numbers of MIRs (1913 loci) at cytogenetic level and we found that MIRs were distributed in a non-random way on human chromosomes, which is consistent with the results of Calin and his colleagues [26]
Summary
Micro-RNA (miRNA) is one of the non-coding RNAs that exist in human genome. miRNAs play an important role in the expression of target genes. Micro-RNA (miRNA) is one of the non-coding RNAs that exist in human genome. MiRNAs play an important role in the expression of target genes. Multiple non-coding RNAs such as micro-RNAs (miRNAs), small nucleolar RNAs (snoRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) exist in human genome [1, 2]. It has been suggested that each MIR is predicted to have multiple potential target mRNAs and a single gene can be modulated by several MIRs [3]. Control of gene expression by MIRs plays an important role in multiple cellular pathways, such as cell proliferation and differentiation, apoptosis, control of cell cycle, migration, invasion, and many tissue-specific functions [1, 4, 5]. Over-expression of MIR-197 and MIR-346 repressed the expression of their predicted target
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