Abstract
Ventricular assist devices (VADs) have been used for treating the end-stage heart failure (HF) patients in the past few decades, which had improved survival rates. In parallel, clinical applications of VADs are accompanied with endangered complications, such as thrombosis, bleeding and infection, which hamper the patient recovery. Non-physiological shear stress (NPSS) is inevitably created during VAD application. When HF patients implanted with VADs, this high level NPSS can induce damage on blood components including blood cells (red blood cells, platelets, leukocytes et al.) and protein (von Willebrand Factor(VWF)). The damage of these blood cells and proteins may lead to the dysfunction of coagulation and immune systems, contributing to complications in VAD patients. To understand how VADs-created NPSS induces blood damage, and find the link between NPSS-induced blood damage and VAD related complications would potentially help to guide the VAD optimization and to find the effect way for treating VAD associated complications. Here we provide a review to investigate what is currently known about NPSS-induced blood damage within VADs and how the NPSS-induced blood damage links to complications (thrombosis, bleeding and infection) in VAD patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.