NONPHAMACOLOGICAL APPROACH TO WEIGHT REDUCTION IN ADULTS WITH HIGH NORMAL BLOOD PRESSURE AND OVERWEIGHT OR OBESITY: PP.28.116

Abstract

Increased body mass is a strong risk factor for hypertension. The aim was to evaluate the effects of dietary weight loss intervention in adults with high normal BP and overweight/obesity. Methods and Results: Working population of men and women aged 25–54 was was observed within the frames of longitudinal epidemiological study. In subjects withb BMI>25 kg/sq and BP 130–139/85–89 mmHg a strong correlation of systolic BP(SBP) and BMI was revealed: p = 0.0001 in women and p=0.0045 in men. The same was true for diastolic BP(DBP): p = 0.0001 in women and p = 0.0001 in men. It was revealed that increase of BMI by 1 kg/sq was associated with increase of SBP by 1.3 in women and by 0.7 mmHg in men (p < 0.05), of DBP increase by 0.7 in men and by 0.9 mmHg in women (p < 0.05). In stepwise regression analysis BM explains 27% of SBP variability and 11% of DBP variability in men. In women - 19% and 17% respectively. Two groups were formed and followed for 3 years. Intervention group consisted of 203 subjects, control group -252. A low-calories diet (1200–1500) and dietician's consultations were used in intervention group. At baseline BM in intervention group was 77.45 ± 1.24 in women and 72.19 ± 1.11(kg) in men; in controls 78.05 ± 1.01 and 69.17 ± 1.90(kg) respectively. Last follow up visit attended 76.6% of the participants. After 3 years a significant weight reduction was observed in the intervention group: 75.02 ± 1.17 in women and 69.56 ± 0.63(kg) in men (p < 0.05). In controls BM increased: 82.07 ± 3.08 in women (p < 0.05) and 75.33 ± 2.89(kg) in men (p < 0.05). BP decreased in the intervention group: - 3.27 for SBP and - 2.09 mmHg for DBP in women; - 1.92 and -1.91 mmHg in men respectively. In control group BP increased: 2.97 mmHg SBP and 1.29 mmHg for DBP in women and 2.56 mmHg and 2.39 mmHg in men respectively (all p < 0.05). Conclusion: Dietary approach to weight loss is effective tool in adults with high normal BP and overweight/obesity.