Abstract

For clinical trials involving (a treatment-wise) incomplete block design and a surrogate variable as a substitute for the primary endpoint, recovery of interblock information in nonparametric analysis of covariance models based on a suitable aligned rank statistics is explored through a combined inference scheme based on intra as well as interblock rank statistics incorporating both the surrogate replicates and the validation samples. Related nonparametrics are presented in detail.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.