NONO and tumorigenesis: More than splicing.

Peifu Feng,Lanqin Cao,Siyuan Qiu,Tanggang Deng,Yan Liu,Lei Zhang,Lin Zhang,Bo Peng,Mao Ye,Wei Xiong,Neng Ling,Ling Li

doi:10.1111/jcmm.15141

Abstract

The non‐POU domain‐containing octamer‐binding protein NONO/p54nrb, which belongs to the Drosophila behaviour/human splicing (DBHS) family, is a multifunctional nuclear protein rarely functioning alone. Emerging solid evidences showed that NONO engages in almost every step of gene regulation, including but not limited to mRNA splicing, DNA unwinding, transcriptional regulation, nuclear retention of defective RNA and DNA repair. NONO is involved in many biological processes including cell proliferation, apoptosis, migration and DNA damage repair. Dysregulation of NONO has been found in many types of cancer. In this review, we summarize the current and fast‐growing knowledge about the regulation of NONO, its biological function and implications in tumorigenesis and cancer progression. Overall, significant findings about the roles of NONO have been made, which might make NONO to be a new biomarker or/and a possible therapeutic target for cancers.

Highlights

The NONO protein, known as 54 kD nuclear RNA- and DNA-binding protein (p54nrb), belongs to the multifunctional DBHS (Drosophila behaviour/human splicing) family of proteins which can bind DNA, RNA and protein.[1]
We have summarized the evidence that NONO plays important roles in human tumorigenesis
NONO is one of partner genes that has been identified as a fusion partner of TFE3 in renal cell carcinoma (RCC)

Summary

Introduction

The NONO (non-POU domain-containing octamer-binding protein) protein, known as 54 kD nuclear RNA- and DNA-binding protein (p54nrb), belongs to the multifunctional DBHS (Drosophila behaviour/human splicing) family of proteins which can bind DNA, RNA and protein.[1].

Results

Conclusion