Non-N-Methyl D-Aspartate Receptors Are Involved in the Hypertension of D5 Dopamine Receptor Knockout Mice.

Abstract

P185 Dopamine receptors are important in the regulation of renal and cardiovascular function. Mice with disrupted D5 dopamine receptors develop vasopressin-dependent hypertension. Systolic and diastolic blood pressures (BP) were higher in homozygous, D5-/- (systolic BP 136±2 mmHg, diastolic BP 103±2 mmHg, n=45) and heterozygous, D5+/- (systolic BP 135±4 mmHg, diastolic BP 100±5 mmHg, n=8) compared with wild type mice, D5+/+ (systolic BP 104±1 mmHg, diastolic BP 79±1 mmHg, n=45). The maximum decrease in mean arterial pressure (MAPmax) caused by blockade of V1 vasopressin receptors [1-(β-mercapto-β, β-cyclopentamethylene propionic acid), 2-(O-methyl) tyrosine]-Arg8-vasopressin, 10 μg/kg) was greater in D5-/- mice (MAPmax -14±3%, n=13, P