Abstract
The actions of excitatory amino acid agonists and antagonists on rod driven horizontal cells were studied in the isolated retina of the rat. Horizontal cells were depolarised by l-glutamate, kainate and quisqualate but not by N-methyl- d-aspartate (NMDA). The broad band excitatory amino acid antagonist, kynurenate and the non-NMDA antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), hyperpolarised horizontal cells, blocking the light responses and also the effects of agonists. In contrast, the competitive NMDA antagonists, 3-[( ± )-2-car☐ypiperazin-4-yl]-propyl-1-phosphonate (CPP) and 2-amino-5-phosphono-pentanoate (AP5) were without effect. Thus, rat horizontal cells possess excitatory amino acid receptors of the non-NMDA type and these mediate their rod driven inputs.
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