Non-Natural Nucleic Acids

Abstract

1. Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs Stella Diafa, Damien Evequoz, Christian J. Leumann, and Marcel Hollenstein 2. Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites, 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine and 2'-Deoxycytidine Na An, Aaron M. Fleming, Nicole C. Rosecrans, Yi Liao, and Cynthia J. Burrows 3. Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue Hui Mei and John Chaput 4. Synthesis of Base-Modified dNTPs through Cross-Coupling Reactions and Their Polymerase Incorporation to DNA Petra Menova, Hana Cahova, Milan Vrabel, and Michal Hocek 5. 2'-C,4'-C-Ethyleneoxy-Bridged 2'-Deoxyribonucleic Acids (EoDNAs) with Thymine Nucleobases: Synthesis, Duplex-Forming Ability, and Enzymatic Stability Takashi Osawa, Satoshi Obika, and Yoshiyuki Hari 6. Synthesis Protocols for Simple Uncharged Glycol Carbamate Nucleic Acids Tanaya Bose and Vaijayanti A. Kumar 7. Synthesis of Nucleobase-Functionalized Morpholino Monomers Bappaditya Nandi, Sankha Pattanayak, Sibasish Paul, Jayanta Kundu, and Surajit Sinha 8. Synthesis and Application of LK T Peptide Nucleic Acids Nathaniel Shank, Kara M. George Rosenker, Ethan A. Englund, Andrew V. Dix, Elizabeth E. Rastede, and Daniel H. Appella 9. Aminoglycoside Functionalization as a Tool for Targeting Nucleic Acids Derrick Watkins, Krishnagopal Maiti, and Dev P. Arya 10. Preparation and Purification of Oligodeoxynucleotide Duplexes Containing a Site-Specific, Reduced, Chemically-Stable Covalent Interstrand Cross-Link between a Guanine Residue and an Abasic Site Maryam Imani Nejad, Xu Guo, Kurt Housh, Christopher Nel, Zhiyu Yang, Nathan E. Price, Yinsheng Wang, and Kent S. Gates 11. Copper-Catalyzed Alkyne-Azide Cycloaddition on the Solid Phase for the Preparation of Fully Click-Modified Nucleic Acids Malte Rosenthal, Franziska Pfeiffer, and Gunter Mayer 12. Labeling Peptide Nucleic Acids with Indium-111 Igor G. Panyutin 13. Site-Specific Labeling of DNA via PCR with an Expanded Genetic Alphabet Michael P. Ledbetter, Denis A. Malyshev, and Floyd E. Romesberg 14. Flexible Nucleic Acids (FNAs) As Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates Maryline Chemama and Christopher Switzer 15. Artificial Nucleosides as Diagnostic Probes to Measure Translesion DNA Synthesis Jung-Suk Choi and Anthony Berdis 16. FRET Assay for Ligands Targeting the Bacterial A-Site RNA Renatus W. Sinkeldam and Yitzhak Tor 17. The Use of Serinol Nucleic Acids as Ultrasensitive Molecular Beacons Keiji Murayama, Hiromu Kashida, and Hiroyuki Asanuma 18. Oligonucleotide Primers with G8AE-Clamp Modifications for RT-qPCR Detection of the Low-Copy dsRNA Timofei S. Zatsepin, Anna M. Varizhuk, Vladimir G. Dedkov, German A. Shipulin, and Andrey V. Aralov 19. Determining Steady-State Kinetics of DNA Polymerase Nucleotide Incorporation Hailey L. Gahlon and Shana J. Sturla