Abstract
Non-Muscle Myosin IIa Heavy Chain Links Squamous-Cell Carcinoma of the Head and Neck to the DNA Damage Response.
Highlights
Direct in vivo RNA interference (RNAi) screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas by Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, Reva B, Fuchs E
Significant efforts have been dedicated to elucidating the molecular drivers of HNSCC genesis and identifying the pathways that sensitize these malignancies to the effects of chemoradiation
Unlike lesions associated with excessive tobacco and alcohol use, TP53 mutations are rarely found in human papilloma virus (HPV)-positive HNSCC, which is generally associated with a favorable clinical course [6]
Summary
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas by Schramek D, Sendoel A, Segal JP, Beronja S, Heller E, Oristian D, Reva B, Fuchs E. Significant efforts have been dedicated to elucidating the molecular drivers of HNSCC genesis and identifying the pathways that sensitize these malignancies to the effects of chemoradiation. No targeted therapies against HPV oncogenes are available for the treatment of patients with HNSCC.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
