Abstract
Non-motor symptoms (NMSs) are a real burden in Parkinson's disease (PD). They may appear in early pre-symptomatic stage as well as throughout the disease course. However, their relationship with the deterioration of the patient's quality of life (QoL) is still under debate. This study aimed to investigate the prevalence of NMSs and their impact on the QoL in a cohort of Moroccan patients. We carried out a cross-transactional study, where a total of 117 patients were submitted to a structured clinical interview and examination investigating motor and NMSs based on common and conventional scales. Motor symptoms were assessed by the UPDRS I-VI during ON condition. The NMSs were evaluated with common scales and their relationship with the QoL was investigated. The mean patient's age was 60.77 ± 11.36 years old, and the median disease duration was 6 years [2.5-9.5]. Motor's phenotype subtypes were the mixed form in 40.2% of patients, akinetic-rigid in 20.5% and a tremor-dominant form in 39.3%. The median Hoehn and Yahr staging was 2 [1-2.5]. Regarding NMSs, the most common were urinary dysfunctions (82.6%), sleep (80.6%), and gastrointestinal (80%) disorders. Other autonomic dysfunctions were also frequent: thermoregulatory dysfunctions 58.6%, cardiovascular troubles 50.9%, and sexual dysfunctions 47.9%. Depression was present in 47.9% and fatigue symptoms in 23.1%. The median score of SCOPA-AUT was 14 [7.75-21.80]. The median PD questionnaire 39-score index (PDQ39-SI) was 23.22% and the most affected dimension was "mobility." Univariate and multivariate analyses showed that the SCOPA-AUT score impacted the QoL (p = 0.001), especially the gastrointestinal (p = 0.007), and cardiovascular (p = 0.049) dimensions. Our data show that all patients have presented at least one NMS. Autonomic and sleep disorders were the most frequent, and in contrast to other studies, digestive and cardiovascular disorders were rather the factors influencing negatively the QoL of patients. Understanding the pathophysiology of these NMSs should be placed at the forefront in order to develop new therapeutic approaches by improving the QoL of PD patients.
Highlights
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases and the number of patients is increasing
This study aimed first to evaluate the prevalence of the non-motor symptoms (NMSs) in a cohort of 117 Moroccan parkinsonian patients and second to determine the impact of NMSs on their quality of life (QoL)
We analyzed the impact of those symptoms on each dimension of the PDQ39-SI and found that the gastrointestinal symptoms affected all the aspects of QoL. They did not influence cognition and communication, nor the stigma dimension, they affected negatively all the other aspects. These findings address the fact that before increasing dopaminergic drugs for patients’ complaints of difficulty in Activities of daily living (ADL) or reduced mobility, one has to exclude the presence of NMSs that do impact mobility and treating them will in some extent, improve motor state of the patients
Summary
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases and the number of patients is increasing. Diverse non-motor symptoms (NMSs), such as sleep disorders, psychiatric disorders, autonomic disabilities, and sensory disturbances are present in PD [8]. These NMSs may contribute to the impairment of patient’s quality of life (QoL). Non-motor symptoms (NMSs) are a real burden in Parkinson’s disease (PD) They may appear in early pre-symptomatic stage as well as throughout the disease course. Their relationship with the deterioration of the patient’s quality of life (QoL) is still under debate. This study aimed to investigate the prevalence of NMSs and their impact on the QoL in a cohort of Moroccan patients
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
