Abstract
Subungual squamous cell carcinoma (SCC) is a rare malignant tumor that originates underneath the nail plate. Its etiology remains unknown, though trauma, chronic infections, immunosuppression, and radiation are possible predisposing factors.1 Here we report the first case of subungual SCC in a 69-year-old man associated with chronic Candida parapsilosis infection and review nonmelanoma subungual malignancies. An association between chronic esophageal candidiasis and esophageal SCC has been described.2 This study draws attention to a possible association between the skin microbiome and carcinogenesis. We describe current treatments and propose a promising alternative radiotherapeutic option.
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