Nonülser dispepside Helikobakter pilori sıklığı ve eradikasyon tedavisine yanıt

Abstract

Background/aim: The etiology of nonulcer dyspepsia is unknown and many factors are suspected. H. pylori is one of the most often accused factors. Our aim was to research the frequency of H. pylori in nonulcer dyspepsia patients and to determine whether H. pylori is more frequent in nonulcer dyspepsia patients than in asymptomatic patients. We also evaluated the symptomatic improvement in H. pylori-positive patients. Materials and methods: 44 nonulcer dyspepsia patients (24 F, 20 M; mean age: 34.36 ± 13.08) were included in the study. 15 asymptomatic individuals (6 F, 9 M; mean age: 32.06 ± 15.09) were included as a control group. Results: H. pylori positivity was 56.8% according to urease test in nonulcer dyspepsia patients, and 20% in the control group. When we classified nonulcer dyspepsia patients to subgroups as ulcer-like, dysmotility-like and reflux-like, H. pylori positivity was 61.9%, 50% and 55.5%, respectively. Eradication therapy was applied to 27 H. pylori- positive patients in whom positivity was established by means of the urease test. Urea breath test was applied to 11 patients 6 weeks after the end of therapy. It was established that infection was eradicated in 5 patients (45.5%). Complaints were continuing in 6 patients in whom eradication was not achieved. Successful results were achieved in 2 of 11 (18.1%) patients by means of eradication therapy. Conclusion: The H. pylori prevalence is higher in patients with nonulcer dyspepsia than in healthy controls, but H. pylori eradication therapy is not useful.