Nonlinear Quantitative Photoacoustic Tomography with Two-Photon Absorption

Abstract

Two-photon photoacoustic tomography (TP-PAT) is a noninvasive optical molecular imaging modality that aims at inferring the two-photon absorption property of heterogeneous media from photoacoustic measurements. In this work, we analyze an inverse problem in quantitative TP-PAT where we intend to reconstruct optical coefficients in a semilinear elliptic PDE, the mathematical model for the propagation of near infrared photons in tissue-like optical media with two-photon absorption, from the internal absorbed energy data. We derive uniqueness and stability results on the reconstructions of single and multiple optical coefficients, and present some numerical reconstruction results based on synthetic data to complement the theoretical analysis.