Nonlinear optimal control for the synchronization of biological neurons under time-delays.

Abstract

The article proposes a nonlinear optimal control method for synchronization of neurons that exhibit nonlinear dynamics and are subject to time-delays. The model of the Hindmarsh-Rose (HR) neurons is used as a case study. The dynamic model of the coupled HR neurons undergoes approximate linearization around a temporary operating point which is recomputed at each iteration of the control method. The linearization procedure relies on Taylor series expansion of the model and on computation of the associated Jacobian matrices. For the approximately linearized model of the coupled HR neurons an H-infinity controller is designed. For the selection of the controller's feedback gain an algebraic Riccati equation is repetitively solved at each time-step of the control algorithm. The stability properties of the control loop are proven through Lyapunov analysis. First, it is shown that the H-infinity tracking performance criterion is satisfied. Moreover, it is proven that the control loop is globally asymptotically stable.