Nonlinear optical and antimicrobial activity of N-acyl glycine derivatives

Abstract

The current paper provides a theoretical and experimental coupled study of synthesized N–octanoyl glycine and N–oleoyl glycine. The derivatives were characterized using nuclear magnetic resonance (1H and 13C NMR), liquid chromatography–mass spectrometry (LC-MS), Fourier–transform infrared (FT-IR), and ultraviolet–visible (UV–Vis) spectroscopy. The resulting N-acyl glycines were assessed for their in vitro antimicrobial activity. The experimental investigation is supported by a linear and nonlinear optical study based on DFT levels and shows that our glycine analogues get moderate hyperpolarizability (β). The β results of these glycines are of moderate amplitude, like those of amino acids. For this, several procedures have been discussed for achieving these β values.