Abstract

The purpose of this research is to investigate a relatively complete model of the fluid volume and osmolality control systems in the human body including the basic nonlinearities. The work is an extension of that published by S. A. Corson and H. R. Weed, by M. Nagaska, S. Koshikawa and K. Suzuki, and by N. Z. Shapiro and DeHaven. Major emphasis is on the inclusion of nonlinear factors and on the consideration of movement of fluid between the intravascular, interstitial and intracellular compartments in dynamic equilibrium.We developed a detailed model of the hormonal feedback associated with water reabsorption in the kidneys. The model accounts for the basic control of the release, action and metabolization of antidiuretic hormone.For easier and more complete simulation of both static and dynamic nonlinearities and for better versatility and accuracy, the model is implemented on a digital computer. The computer results are compared with physiological data in response to different water loads and to dehydration to validate the accuracy of the model. Diabetes insipidus is simulated and the results compared with medical data.It is believed that this model offers analytic details and capability with accuracy not previously available. The research is being continued to include additional nonlinearities and control factors and to remove limiting approximations.

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