Nonlinear effects of transcranial direct current stimulation over the primary motor cortex with different stimulation intensity and duration

Abstract

Event Abstract Back to Event Nonlinear effects of transcranial direct current stimulation over the primary motor cortex with different stimulation intensity and duration Mohsen S. Mosayebi1, Desmond Agboada1, Asif Jamil1, Michael Nitsche1, 2 and Min-Fang Kuo1* 1 Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo), Germany 2 Berufsgenossenschaftliches Universitätsklinikum, Germany Transcranial direct current stimulation (tDCS) can non-invasively induce polarity-dependent excitability alterations in the human motor cortex lasting more than an hour after stimulation. Clinical applications with encouraging results have been reported, but the optimal stimulation protocols remain to be determined. Here we explored the effect of different stimulation parameters (intensity/duration) on cathodal tDCS-induced neuroplasticity in the primary motor cortex. Cathodal tDCS was applied with the combinations of four intensities (sham, 1, 2 and 3mA) and tree durations (15, 20 and 30mins) in 16 young healthy subjects and the after-effects were monitored with TMS-induced motor evoked potentials (MEP) right after tDCS, and until the next day evening. The results revealed nonlinear after-effects: 1mA-15min, 1mA-30min and 3mA-20 min cathodal tDCS induced LTD-like plasticity, while LTP-like plasticity was observed after 2mA-20min stimulation. Our study provides further insights on the dependency of tDCS-induced neuroplasticity from stimulation parameters, and therefore delivers crucial information for future clinical applications. Acknowledgements This project was funded by the research grant from the German Federal Ministry of Research and Education (BMBF) (GCBS grant 01EE1501, TRAINSTIM grant 01GQ1424E) Keywords: Neuroplasicity,, noninvasive brain stimulation, Transcranial direct cortical stimulation (tDCS), transcrancial magnetic stimulation, primary motor cortex, Depression Conference: Belgian Brain Congress 2018 — Belgian Brain Council, LIEGE, Belgium, 19 Oct - 19 Oct, 2018. Presentation Type: e-posters Topic: NOVEL STRATEGIES FOR NEUROLOGICAL AND MENTAL DISORDERS: SCIENTIFIC BASIS AND VALUE FOR PATIENT-CENTERED CARE Citation: Mosayebi MS, Agboada D, Jamil A, Nitsche M and Kuo M (2019). Nonlinear effects of transcranial direct current stimulation over the primary motor cortex with different stimulation intensity and duration. Front. Neurosci. Conference Abstract: Belgian Brain Congress 2018 — Belgian Brain Council. doi: 10.3389/conf.fnins.2018.95.00012 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Jul 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Min-Fang Kuo, Leibniz-Institut für Arbeitsforschung an der TU Dortmund (IfADo), Dortmund, Germany, kuo@ifado.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Mohsen S Mosayebi Desmond Agboada Asif Jamil Michael Nitsche Min-Fang Kuo Google Mohsen S Mosayebi Desmond Agboada Asif Jamil Michael Nitsche Min-Fang Kuo Google Scholar Mohsen S Mosayebi Desmond Agboada Asif Jamil Michael Nitsche Min-Fang Kuo PubMed Mohsen S Mosayebi Desmond Agboada Asif Jamil Michael Nitsche Min-Fang Kuo Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.