Abstract

In a multicentric European survey,1 cephalosporins were responsible for 10% to 40% of β-lactam hypersensitivity reactions. Adverse reactions to ceftaroline, a broad-spectrum, fifth-generation parenteral cephalosporin, were reported in 10% to 20% of inpatients, a fifth of which were suspected hypersensitivity reactions.2 Establishing nonirritant concentrations (NICs) for skin tests (STs) is critical to ascertain the optimal balance of sensitivity and specificity, improve antibiotic stewardship for the patient, and reduce the costs of health systems.

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