Abstract
Background and objectivesIn this study we use vibrational optical coherence tomography (VOCT) to study the mechanovibrational peak heights exhibited by benign and cancerous skin lesions. When a tissue is vibrated using audible sound it resonates at frequencies that represent the major components. The resonant frequency is related to the elastic modulus through a calibration equation developed in vitro using isolated tissue components. New cancerous skin lesions were identified based on the presence of a new cellular peak (80 Hz) with increased stiffness, a new blood vessel peak (130 Hz) that appears to be less stiff than normal blood vessels (150 Hz), and a fibrous tissue peak (260 Hz) present in carcinomas. The objective of this study was to differentiate different skin cancers using VOCT.
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