Non-Invasive Prenatal Diagnosis in Twin Pregnancies: Current Status

Abstract

The objective of this review is to assess the evidence which supports the use of non-invasive prenatal diagnosis (NIPD) in twin pregnancies. Through the years, we have witnessed the technological developments in non-invasive prenatal diagnosis attained new heights, but those studies were usually limited in singleton pregnancies. As we known, twin pregnancies are at higher risk in both aneuploidy and structural abnormalities. The first- and second- trimester aneuploidy screening in twin gestations are less accurate than in singleton gestations. And the invasive prenatal diagnosis in twin pregnancies is associated with a high risk of pregnancy loss. So, it is urgent to develop accurate non-invasive prenatal diagnosis in twin pregnancies. Recent studies about different terminology and methods in NIPD of twin pregnancies have been reported, suggesting that non-invasive prenatal testing can be feasibly and reliably used in twin pregnancies. In this article, we summarized the published literature on non-invasive prenatal diagnosis in twin pregnancies in order to benefit our clinical practice.