Abstract
Background The aim of this study was to compare 3 different available methods for estimating left ventricular end-diastolic pressure (LVEDP) noninvasively in patients with coronary artery disease and preserved left ventricular ejection fraction (EF). Methods We used 3 equations for noninvasive estimation of LVEDP: The equation of Mulvagh et al., LVEDP 1 = 46 − 0.22 (IVRT) − 0.10 (AFF) − 0.03 (DT) − (2 ÷ E/A) + 0.05 MAR; the equation of Stork et al., LVEDP 2 = 1.06 + 15.15 × Ai/Ei; and the equation of Abd-El-Aziz, LVEDP 3 = [0.54 (MABP) × (1 − EF)] − 2.23. (Abbreviations: A, A-wave velocity; AFF, atrial filling fraction; Ai, time velocity integral of A wave; DT, deceleration time; E, E-wave velocity; Ei, time velocity integral of E wave; IVRT, isovolumic relaxation time; MABP, mean arterial blood pressure; MAR, time from termination of mitral flow to the electrocardiographic R wave; Ti, time velocity integral of total wave.) Results LVEDP measured by catheterization was correlated with LVEDP 1 ( r = 0.52, P < 0.001), LVEDP 2 ( r = 0.31, P < 0.05), and LVEDP 3 ( r = 0.81, P < 0.001). Conclusions The equation described by Abd-El-Aziz, LVEDP = [0.54 MABP × (1 − EF)] − 2.23, appears to be the most accurate, reliable, and easily applied method for estimating LVEDP noninvasively in patients with preserved left ventricular ejection fraction and an LVEDP < 20 mm Hg.
Published Version
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