Abstract

A non-invasive method to determine the optical property of biological tissue by the combination with ultrasound modulation and diffuse reflection light is firstly presented. A focused ultrasound beam through tissue has the modulated diffuse light located within the focal spot and so that the diffuse fluence distribution is easily detected from out of tissue. Based on the diffuse reflectance fitted formula concluded from Monte Carlo simulation by authors, the optical property including absorption coefficient, scattering coefficient, average scattering cosine, and even the refractive index can be rebuild. In addition, this new method is very significant to measure a light dose in vivo in laser medicine and surgery.

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