Abstract
Background and Aim: Cirrhosis and portal hypertension are characterised by a hyperdynamic circulation, which is independently associated with portal pressure and variceal size. Measurement is invasive and performed in limited centres; non-invasive techniques are available. We assessed whether non-invasive measurement of systemic haemodynamics can identify the hyperdynamic circulation and its associations with portal pressure and variceal size. Methods: We studied 29 cirrhotic patients. Systemic haemodynamics were studied non-invasively using the Finometer® (cardiac output/index CO/CI, heart rate HR, peripheral vascular resistance PVR). Gastroscopy assessed variceal presence, size and bleeding risk. Portal pressure was assessed by hepatic venous pressure gradient (HVPG). Results: A significant negative correlation was seen between CO and PVR (r= -0.95, p<0.001). Significant positive correlations were seen between CI, HR, HVPG and ChildPugh score (r=0.36, r=0.37 and r=0.58 respectively). HVPG correlated positively with HR and CI (r=0.62, p<0.001 and r=0.53, p=0.05 respectively). Significant differences in haemodynamic parameters were seen according to variceal size.
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