Abstract
In 1912, Krogh and Lindhard(1) calculated pulmonary blood flow by measurement of the difference in gas concentrations between two alveolar samples during an interrupted expiration, following a single, maximal inspiration of nitrous oxide. This estimation contained a number of physiological and physical errors; however, it formed the basis for the subsequent development of more sophisticated techniques for calculation of functional pulmonary capillary blood flow and pulmonary tissue volume by measurement of the rate of uptake of a soluble gas from alveoli.
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