Abstract
Abstract : The goals of this application are to develop methods to non-invasively differentiate fast and slow growing prostate tumors and also develop methods to evaluate response to anti-angiogenic agents. Validation of the results will be based on tumor growth, metastases, and microvessel density measurement (anti-angiogenic studies). To date, we have focused on optimizing the pulse sequences necessary for lactate detection, synthesizing a macromolecular contrast agent and optimizing its use. These goals have been more difficult to achieve but we are now able to localize lactate within an image plane of the tumor and have finished synthesizing the macromolecular contrast agent and optimizing its use.
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