Abstract
Diabetes has become a chronic metabolic disorder, and the growing diabetes population makes medical care more important. We investigated using a portable and noninvasive contact lens as an ideal sensor for diabetes patients whose tear fluid contains glucose. The key feature is the reversible covalent interaction between boronic acid and glucose, which can provide a noninvasive glucose sensor for diabetes patients. We present a phenylboronic acid (PBA)-based HEMA contact lens that exhibits a reversible swelling/shrinking effect to change its thickness. The difference in thickness can be detected in a picture taken with a smartphone and analyzed using software. Our novel technique offers the following capabilities: (i) non-enzymatic and continuous glucose detection with the contact lens; (ii) no need for an embedded circuit and power source for the glucose sensor; and (iii) the use of a smartphone to detect the change in thickness of the contact lens with no need for additional photo-sensors. This technique is promising for a noninvasive measurement of the glucose level and simple implementation of glucose sensing with a smartphone.
Highlights
Diabetes is one of the most common metabolic disorders in the world, with more than 400 million people currently affected [1,2]
3-phenylboronic acid was modified on the fabricated poly-Hydroxyethyl methacrylate (HEMA) contact lens as follows
A stable distance for detecting the thickness of the purely synthetic boronic acid (PBA)-based HEMA contact lens was used as the the platform with a smartphone
Summary
Diabetes is one of the most common metabolic disorders in the world, with more than 400 million people currently affected [1,2]. The contact lens can serve as a portable noninvasive blood glucose measurement device for continuous health monitoring when equipped with a sensor to detect physiological changes and metabolites in tears [29,33,34,35]. Such a system provides many capabilities, some issues remain, including the encapsulation of electronic chip materials and metal wireless circuits for the sensor in the contact lens. A portable noninvasive contact lens with an imaging program in a smartphone for an ideal methodfor for sensing sensing diabetes teartear fluid contains glucose.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
