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Abstract
Here we propose a simple noninvasive approach to determine the depth of a buried object using transmission Raman spectroscopy. In accordance with theory, the photons arising from spectral peaks that are suitably separated will be subjected to different optical properties in the media through which they travel. These differences can impact the relative intensities of Raman peaks as a function of the transmission path length, thereby the depth of signal generation is inherently encoded in the spectra. In a proof-of-concept study, through only external calibrations, it was possible to accurately predict the depth of Polytetrafluoroethylene (PTFE) layer purely on the basis of relative intensity of two peaks in a predominantly absorbing solution Indian ink (0.1 μL/mL; RMSE 0.42 mm) and a scattering solution (RMSE 0.50 mm). This simple approach offers the possibility to noninvasively identify the depth of a buried object, such as breast calcifications, using simple transmission measurement geometries for the first time.
Highlights
The recent development of deep Raman spectroscopy, an array of methods for subsurface analysis of turbid media, has opened a number of analytical fields including pharmaceutical analysis in quality control and disease diagnosis.[1]
Other recent innovations to recover depth information using Transmission Raman Spectroscopy (TRS) involved the addition of optical elements at the sample surface acting as a “photon dioide”
We proposed a much simpler and more broadly applicable method enabling the depth of a single, chemically distinct object buried within a turbid matrix to be determined through monitoring the differential transmittance of two or more discrete Raman bands
Summary
The recent development of deep Raman spectroscopy, an array of methods for subsurface analysis of turbid media, has opened a number of analytical fields including pharmaceutical analysis in quality control and disease diagnosis.[1]. Other recent innovations to recover depth information using TRS involved the addition of optical elements (band-pass filter) at the sample surface acting as a “photon dioide”.8 Here we proposed a much simpler and more broadly applicable method enabling the depth of a single, chemically distinct object buried within a turbid matrix to be determined through monitoring the differential transmittance of two or more discrete Raman bands.
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