Abstract
As cancer ranks among the most common diseases worldwide, its early diagnosis has become a key point of clinical oncology. Such a diagnosis has been accomplished using a number of techniques; however, some of them show low sensitivity. Conventional laboratory methods are expensive and usually cannot identify lesions in an early stage or are provided in an invasive way. Therefore, it is necessary to find an easy and noninvasive protocol for detecting cancer. An early and noninvasive diagnosis of malignancies offers the opportunity of early therapy and concomitantly a higher chance of healing and/or survival. Nowadays, several new alternative methods are employed in cancer diagnosis. One of them is native fluorescence analysis of biological fluids. Compared with a healthy organism, the metabolism of cancerous tissue is altered, leading to the altered fluorescent characteristics of biological fluids. This review examines the potential application of autofluorescence analysis of biological fluids in clinical diagnosis.
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