Abstract
Background and Purpose: The objective of the present study was to investigate cortical neuronal and vascular changes as well as their interaction in physiological and pathological conditions. Using simultaneously non-invasive DC-magnetoencephalography (dcMEG) and multichannel, time-resolved near-infrared spectroscopy (trNIRS) the changes in neuronal and vascular signals as well as their coupling processes were characterized. We used a unique DC-MEG recording technique which became feasible inside the new Berlin magnetically shielded room (BMSR 2). This technique allows to characterize fast dynamics of neurovascular coupling from DC up to the kHz frequency range. This is of great importance, e.g., for the description of transition phenomena at beginning and end of long lasting activations.
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