Noninvasive Assessment of Liver Stiffness in Patients Undergoing the Fontan Procedure.

Abstract

Hepatic derangements and liver injury following the Fontan operation (FO) may progress in some cases to hepatic fibrosis (HF) and cirrhosis. The respective roles of transient elastography (TE) or FibroScan, shear wave elastography (SWE), and aspartate transaminase to platelet ratio index (APRI) in assessing liver stiffness (LS) and possible liver injury in these patients are unclear. Thirty-nine patients (31 males), mean age 11.8 ± 5.7 years, median 11 years (interquartile range: 7-14.7 years), undergoing the FO between November 2017 and December 2018 were included. Liver stiffness and HF assessment was done with TE, SWE, and APRI in the preoperative period and postoperatively at 3-, 6-, and 12-month interval. The LS values increased over time (postoperative values at 3, 6, and 12 months) as compared to preoperative values by both FibroScan and SWE. The change in liver stiffness measurement (LSM) was statistically significant: LSM0 to LSM3 (P ≤ .0001), LSM0 to LSM6 (P ≤ .0001), and LSM0 to LSM12 (P = .001). Similarly, significant changes were observed on SWE: SWE0 to SWE3 (P ≤ .0001), SWE0 to SWE6 (P ≤ .0001), and SWE0 to SWE12 (P = .001). There was no significant change in the APRI values over time. Noninvasive methods such as FibroScan and SWE may be of use to assess LS in follow-up of patients undergoing the FO for early recognition of hepatic changes.