Abstract
Results We analyzed data from 87 patients, 68 (78.2%) of which had chronic HBV infection and 19 (21.8%), chronic HCV infection. The median age was 44.9 ± 15.0 (range 17-75). The mean body mass index (BMI) was 26.0 ± 3.6 in the HBV group and 26.7 ± 3.2 in the HCV group. Overall, 36 patients (41.4%) had normal BMI, another 36 (41.4%) had a BMI equivalent for overweight status, and 15 (17.2%) had grade I obesity. The distribution of FibroMeter results was: F0-F1: 8 (9.2%), F1: 2 (2.3%), F1-F2: 43 (49.4%), F2: 11 (12.6%), F2F3: 8 (9.2%), F3: 7 (8.0%), F3-F4: 8 (9.2%). The distribution of the necroinflammatory activity was: A0-A1: 16 (18.4%), A1-A2: 52 (59.8%), A2-A3: 19 (21.8%). We identified no statistically significant differences between patients with HBV and HCV regarding mean fibrosis scores (p = 0.476) or mean necroinflammatory activity scores (p = 0.681). Conclusion The patients included in this study had varied ages and characteristics. FibroMeter classified most of them as F1-F2 but descriptive data should be interpreted in clinical context and potential confounding factors should be identified on a case-by-case basis.
Highlights
Since the advent of non-invasive methods for liver fibrosis assessment, liver biopsy has been increasingly replaced with liver stiffness measurements or with computed scores based on serum biomarkers, for monitoring viral infections such as HBV [1] or HCV [2,3]
FibroMeter classified most of them as F1-F2 but descriptive data should be interpreted in clinical context and potential confounding factors should be identified on a case-by-case basis
36 patients (41.4%) had normal body mass index (BMI), another 36 (41.4%) had a BMI equivalent for overweight status, and 15 (17.2%) had grade I obesity
Summary
Since the advent of non-invasive methods for liver fibrosis assessment, liver biopsy has been increasingly replaced with liver stiffness measurements or with computed scores based on serum biomarkers, for monitoring viral infections such as HBV [1] or HCV [2,3]
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