Abstract
Left ventricular (LV) remodeling after myocardial infarction (MI) plays an important role in the progression of heart failure (HF). Changes in the shape, size, and function of the LV are caused by altered mechanical properties of the injured myocardium. As the survival rate after MI improves with medical advances, the incidence of HF patients increases. Hence, an accurate depiction of the LV remodeling process facilitates disease surveillance and monitoring of therapeutic efficacy. It may also help determine the choice of treatment, e.g., surgery to remove the infarcted wall segment and reduce the LV cavity size. Traditionally, there are several ways of characterizing LV remodeling: changes in LV diameter, LV volume, ejection fraction, and qualitative or semi-quantitative descriptors of LV shape. In this chapter, we present a new approach to quantify LV shape (in terms of curvedness), wall stress, and function by using computational modeling.
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