Abstract
Transmitral flow velocity pattern obtained by pulsed Doppler technique reflects left ventricular (LV)diastolic function, but an increase in left atrial pressure pseudo-normalizes the flow pattern and masks diastolic dysfunction. Flow propagation velocity (FPV) measured, using color M-mode Doppler and baseline-shift technique, represents an average velocity of early diastolic LV filling flow from mitral orifice to mid-ventricle. In patients with ischemic heart disease and dilated cardiomyopathy, including those with pseudonormalized transmitral flow pattern, FPV had good correlation with the time constant of early diastolic LV pressure decay (Tau), indicating that FPV is a useful noninvasive diastolic-function parameter which does not pseudo-normalize. Unlike the conventional Doppler parameters, FPV was well correlated with Tau in patients with hypertrophic cardiomyopathy, and was distinctly decreased even in hypertensive patents without LV hypertrophy. Thus, FPV is a unique noninvasive diastolic parameter, which can sensitively and accurately detect LV diastolic impairment.
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