Abstract
Cardiovascular diseases are one of most frequent cause of morbidity and mortality in the world. There is an emerging need for integrated, non-invasive, and easy-to-use clinical tools to assess accurately cardiovascular system primarily in the preventative medicine. We present a novel design for a non-invasive pulse wave velocity (PWV) assessment method integrated in a single brachial blood pressure monitor allowing for up to 100 times more sensitive recording of the pressure pulsations based on a brachial occlusion-cuff (suprasystolic) principle. The monitor prototype with built-in proprietary method was validated with a gold standard reference technique SphygmoCor VX device. The blood pressure and PWV were assessed on twenty-five healthy individuals (9 women, age (37 ± 13) years) in a supine position at rest by a brachial cuff blood pressure monitor prototype, and immediately re-tested using a gold standard method. PWV using our BP monitor was (6.67 ± 0.96) m/s compared to PWV determined by SphygmoCor VX (6.15 ± 1.01) m/s. The correlation between methods using a Pearson’s correlation coefficient was r = 0.88 (p < 0.001). The study demonstrates the feasibility of using a single brachial cuff build-in technique for the assessment of the arterial stiffness from a single ambulatory blood pressure assessment.
Highlights
Cardiovascular diseases are one of the most important causes of morbidity and mortality in the world
For the purpose of the study, we have developed a prototype of blood pressure (BP) monitor using unique hardware and software features
The aim of the study was to present a novel, proprietary method for ad non-invasive measurement of pulse wave velocity (PWV) based on the cuff occlusion and to test how the method compares to ground truth using a gold standard measurement device SphygmoCor VX
Summary
Cardiovascular diseases are one of the most important causes of morbidity and mortality in the world. Known risk factors include smoking, arterial hypertension, hyperlipidemia, diabetes, metabolic syndrome, etc. Cardiovascular mortality has declined in developed countries as a result of better treatment and prevention in recent decades, the identification of individuals with higher risk is very important and can prevent severe consequences [1]. Preventive intervention can lead to delaying or even averting their manifestations. Besides the blood pressure (BP), arterial stiffness is one of options to assess the risks since it is associated with pathophysiology of arterial hypertension and is often evaluated by measuring pulse wave velocity (PWV). The aortic stiffness is one of determinant of the absolute central versus peripheral BP (e.g., arm) difference; it has been recognized
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