Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M Hackeng ,Els Nieveen Van Dijkum,Joo Young Kim,Vincenzo Corbo,Jacqueline A Brosnan-Cashman ,Samantha Bersani,Randall E Brand ,Marina N Nikiforova ,Rohit Das,Seung Mo Hong ,Nathan Bahary,David A Geller ,Koen M.a Dreijerink ,Rita T Lawlor ,J Wallis Marsh ,Boris Rusev,Adam Slivka,Menno R Vriens ,Luca Landoni,Roderick J O’sullivan ,Xinhui Han ,Harkirat Singh,You Na Sung ,Herbert J Zeh ,Muaz Aijazi,James F Pingpank ,Michelle Heayn,Kenneth Lee,Antonio Pea,Kenneth E Fasanella ,Folkert H.m Morsink ,Christopher M Heaphy ,Kevin Mcgrath,Andrea Mafficini,Michèle Milella ,Sara Cingarlini,Lodewijk A.a Brosens ,Melanie Ongchin,G Johan A Offerhaus ,Savreet Sarkaria,Ta‐Chiang Liu ,Roberto Salvia,Michael A Nalesnik ,Claudio Luchini,Dengfeng Cao,Asif Khalid,Soyeon An,Amer H Zureikat ,Jennifer Chennat,Melissa E Hogg ,Alessandro Paniccia,Aldo Scarpa,Charlotte M Heidsma ,Gerlof D Valk ,Massimo Milione,Aatur D Singhi

doi:10.1136/gutjnl-2020-322595

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M Hackeng , Els Nieveen Van Dijkum + Show 54 more

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https://doi.org/10.1136/gutjnl-2020-322595

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Journal: Gut	Publication Date: Apr 13, 2021
Citations: 83	License type: open-access

Affiliation: University Medical Center Utrecht, Utrecht University, Amsterdam University Medical Centers, Eulji University, University of Verona, Johns Hopkins University, University of Pittsburgh Medical Center, Asan Medical Center, University of Ulsan, Ulsan College, West Virginia University, University of Pittsburgh, The University of Texas Southwestern Medical Center, Boston University, Washington University in St. Louis, Incheon St. Mary's Hospital, NorthShore University HealthSystem, Fondazione IRCCS Istituto Nazionale dei Tumori, UPMC Health System

#Alternative Lengthening Of Telomeres #Non-functional Pancreatic Neuroendocrine Tumours + Show 8 more

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Abstract

ObjectiveRecent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic...

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