Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size

Wenzel M Hackeng ,Vincenzo Corbo,Els Nieveen Van Dijkum,Joo Young Kim,Jacqueline A Brosnan-Cashman ,Marina N Nikiforova ,Amer H Zureikat ,Folkert H.m Morsink ,Claudio Luchini,Koen M.a Dreijerink ,David A Geller ,Soyeon An,Andrea Mafficini,Roberto Salvia,G Johan A Offerhaus ,You Na Sung ,Michael A Nalesnik ,Rohit Das,Ta‐Chiang Liu ,Seung Mo Hong ,Michèle Milella ,Nathan Bahary,James F Pingpank ,Kenneth Lee,Harkirat Singh,Melissa E Hogg ,Xinhui Han ,J Wallis Marsh ,Massimo Milione,Boris Rusev,Antonio Pea,Gerlof D Valk ,Lodewijk A.a Brosens ,Aldo Scarpa,Muaz Aijazi,Samantha Bersani,Charlotte M Heidsma ,Michelle Heayn,Luca Landoni,Savreet Sarkaria,Menno R Vriens ,Adam Slivka,Melanie Ongchin,Jennifer Chennat,Randall E Brand ,Roderick J O’sullivan ,Kevin Mcgrath,Dengfeng Cao,Kenneth E Fasanella ,Sara Cingarlini,Alessandro Paniccia,Asif Khalid,Rita T Lawlor ,Herbert J Zeh ,Christopher M Heaphy ,Aatur D Singhi

doi:10.1136/gutjnl-2020-322595

Abstract

ObjectiveRecent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic...

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