Nonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology.

Abstract

HomeCirculationVol. 81, No. 2Nonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBNonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology. J L Fleiss, J T BiggerJr, M McDermott, J P Miller, T Moon, A J Moss, D Oakes, L M Rolnitzky and T M Therneau J L FleissJ L Fleiss Search for more papers by this author , J T BiggerJrJ T BiggerJr Search for more papers by this author , M McDermottM McDermott Search for more papers by this author , J P MillerJ P Miller Search for more papers by this author , T MoonT Moon Search for more papers by this author , A J MossA J Moss Search for more papers by this author , D OakesD Oakes Search for more papers by this author , L M RolnitzkyL M Rolnitzky Search for more papers by this author and T M TherneauT M Therneau Search for more papers by this author Originally published1 Feb 1990https://doi.org/10.1161/01.CIR.81.2.684Circulation. 1990;81:684–685"Nonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology.." Circulation, 81(2), pp. 684–685 Previous Back to top Next FiguresReferencesRelatedDetailsCited By (2011) References Biostatistical Methods, 10.1002/9780470907412.refs, (593-616) Yusuf S and Negassa A (2002) Choice of clinical outcomes in randomized trials of heart failure therapies: Disease-specific or overall outcomes?, American Heart Journal, 10.1067/mhj.2002.119770, 143:1, (22-28), Online publication date: 1-Jan-2002. Freedman B, Wuerth J, Cartwright K, Bain R, Dippe S, Hershon K, Mooradian A and Spinowitz B (1999) Design and Baseline Characteristics for the Aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II), Controlled Clinical Trials, 10.1016/S0197-2456(99)00024-0, 20:5, (493-510), Online publication date: 1-Oct-1999. Doval H, Nul D, Grancelli H, Perrone S, Bortman G and Curiel R (1994) Randomised trial of low-dose amiodarone in severe congestive heart failure, The Lancet, 10.1016/S0140-6736(94)91895-3, 344:8921, (493-498), Online publication date: 1-Aug-1994. Hansen J (1994) Review of postinfarct treatment with verapamil: Combined experience of early and late intervention studies with verapamil in patients with acute myocardial infarction, Cardiovascular Drugs and Therapy, 10.1007/BF00877222, 8:S3, (543-547), Online publication date: 1-Aug-1994. Petretta M, Cuocolo A, Carpinelli A, Nicolai E, Valva G, Bianchi V, Salemme L, Salvatore M and Bonaduce D (1994) Prognostic value of myocardial hypoperfusion indexes in patients with suspected or known coronary artery disease, Journal of Nuclear Cardiology, 10.1007/BF02939954, 1:4, (325-337), Online publication date: 1-Jul-1994. Petretta M, Bonaduce D, Bianchi V, Vitagliano G, Conforti G, Rotondi F, Themistoclakis S and Morgano G (1992) Characterization and prognostic significance of silent myocardial ischemia on predischarge electrocardiographic monitoring in unselected patients with myocardial infarction, The American Journal of Cardiology, 10.1016/0002-9149(92)90145-O, 69:6, (579-583), Online publication date: 1-Mar-1992. (1992) Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions, New England Journal of Medicine, 10.1056/NEJM199209033271003, 327:10, (685-691), Online publication date: 3-Sep-1992. Pfisterer M, Salamin P, Schwendener R and Burkart F (1992) Clinical Risk Assessment After First Myocardial infarction—Is Additional Noninvasive Testing Necessary?, Chest, 10.1378/chest.102.5.1499, 102:5, (1499-1506), Online publication date: 1-Nov-1992. Bunch F, Thornton J, Cohen M and Downey J (1992) Adenosine is an endogenous protectant against stunning during repetitive ischemic episodes in the heart, American Heart Journal, 10.1016/0002-8703(92)90055-Z, 124:6, (1440-1446), Online publication date: 1-Dec-1992. Akiyama T, Pawitan Y, Greenberg H, Kuo C, Reynolds-Haertle R and The CAST Investigators (1991) Increased risk of death and cardiac arrest from encainide and flecainide in patients after non-Q-wave acute myocardial infarction in the Cardiac Arrhythmia Suppression Trial, The American Journal of Cardiology, 10.1016/0002-9149(91)90308-8, 68:17, (1551-1555), Online publication date: 1-Dec-1991. Gilpin E, Ricou F, Dittrich H, Nicod P, Henning H and Ross J (1991) Factors associated with recurrent myocardial infarction within one year after acute myocardial infarction, American Heart Journal, 10.1016/0002-8703(91)90712-Q, 121:2, (457-465), Online publication date: 1-Feb-1991. Califf R, Harrelson-Woodlief L and Topol E (1990) Left ventricular ejection fraction may not be useful as an end point of thrombolytic therapy comparative trials., Circulation, 82:5, (1847-1853), Online publication date: 1-Nov-1990. Shrout P and Begg M (2005) Fleiss, Joseph L. Encyclopedia of Biostatistics, 10.1002/0470011815.b2a17159 Shrout P and Begg M (2014) F leiss, J oseph L Wiley StatsRef: Statistics Reference Online, 10.1002/9781118445112.stat04845 February 1, 1990Vol 81, Issue 2 Advertisement Article InformationMetrics Copyright © 1990 by American Heart Associationhttps://doi.org/10.1161/01.CIR.81.2.684 Originally publishedFebruary 1, 1990 PDF download Advertisement