Abstract
Background & Objectives:Lipoprotein-A has been recognized as a risk factor for ischemic heart diseases. Myocardial infarction (MI) is common complication of ischemic heart disease. Diabetes play an incremental role in the development of coronary artery disease (CAD), however still there are conflicting data regarding the relationship of Lipoprotein-B and MI. We therefore wanted to evaluate the relationship of Lipo-B, MI and diabetes mellitus. Our objective was to determine the non-fasting Apo-lipoprotein B and triglycerides level among type II diabetic patients with ischemic heart disease and to compare with type II diabetic without ischemic heart disease.Methods:This was cross sectional study where two groups of patients were recruited in the study, Group-I included patient with Ischemic Heart Disease and diabetes while Group-II comprised of diabetes without Ischemic Heart Disease. Age, sex and basic demographic matching was done between the two groups. Data were collected using random sample. The comparative approach was used to see the role of diabetes in the elevation of Apo-lipoprotein B level, which is a risk factor for Ischemic heart diseases.Results:Two hundred forty eight patients (Cases: 123 Diabetic with myocardial infarction and (Control: 125 Diabetic without myocardial infarction) were included in the study. Mean Apo-B among diabetic patients with myocardial infarction was high (68.3±24.23 ng/ml) compared to non-cardiac patients (49.97±33.880 ng/ml) with a p <0.000. Marked difference was also observed in triglycerides levels where it was found very high (301.4±55.1 mg/dL) in patients of diabetes with myocardial infarction as compared to subjects without MI (137.7±84.7 mg/dL). There was positive correlation between Apo-lipoprotein and Triglycerides (P value=039).Conclusion:Based on the study result it was concluded that Apo-lipoprotein and triglycerides in diabetic patients with myocardial infarction, had higher levels compared to diabetic patients without Myocardial infarction and this could be a consequence of increase in age, insulin resistance and deficiency of insulin in the body. We also found positive correlation between Apo-lipoprotein and Triglycerides.
Highlights
Diabetes Mellitus is one of the major risk factors of coronary heart diseases
The results indicated that mean ± SD Apo-B among diabetic patients with myocardial infarction was high 68.3±24.230 ng/mL as compared to non-cardiac patients 49.97±33.880 ng/mL, which accounted for a mean difference of 18.341 ng/ml (CI; 10.97 - 25.70 ng/ mL) indicating statistically significant difference (p =
Our findings show an increase in plasma triglyceride levels among diabetic patients with myocardial infarction (Group-A) as compared to diabetic patients without myocardial infarction (Group-B)
Summary
Diabetes Mellitus is one of the major risk factors of coronary heart diseases. Despite availability of effective glycemic control regimes, diabetes mellitus still remains associated with the risk of developing coronary heart diseases.[1,2,3] Large number of clinical and research evidences indicate that both diabetic mellitus and insulin resistance lead to endothelialPak J Med Sci March - April 2018 Vol 34 No 2 www.pjms.com.pk 247Nayyer-uz-Zaman et al.dysfunctions which in turn increase the risk of atherogenic function of the vascular endothelium.[1] among diabetic patients, prevention of endothelial dysfunction may be critical for preventing atherosclerosis and ischemic heart disease. It is evident that hyperglycemia is allied with mildly increased levels of myeloperoxidase, independent of other clinical variables This linkage may account for accelerated progression of the atherosclerosis in diabetic patients. Our objective was to determine the non-fasting Apo-lipoprotein B and triglycerides level among type II diabetic patients with ischemic heart disease and to compare with type II diabetic without ischemic heart disease. The comparative approach was used to see the role of diabetes in the elevation of Apo-lipoprotein B level, which is a risk factor for Ischemic heart diseases. Conclusion: Based on the study result it was concluded that Apo-lipoprotein and triglycerides in diabetic patients with myocardial infarction, had higher levels compared to diabetic patients without Myocardial infarction and this could be a consequence of increase in age, insulin resistance and deficiency of insulin in the body.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
