Non-enzymatic lactic acid sensor based on AuPtNPs functionalized MoS2 nanosheet as electrode modified materials

Abstract

Lactic acid (LA) is an energy product of anaerobic metabolism and also used as an important biomarker in clinical medical diagnosis. Herein, a facile and efficient non-enzymatic electrochemical sensor had been successfully developed to determine LA using gold platinum bimetallic nanoparticles modified molybdenum disulfide nanosheet (MoS 2 -AuPt) as a sensing platform. The presence of AuPtNPs not only increased the electron transfer rate but also could replace enzymes for electrochemical oxidation of LA. Thus, MoS 2 -AuPt could be acted as an efficient electrocatalyst for non-enzymatic LA detection. Finally, the non-enzymatic LA sensor was used to detect different concentrations of LA, its linear range was 0.005–3 mM, the detection limit was 0.00033 mM, and the response time was less than 15 s. Moreover, the developed LA sensor had been successfully applied to detect LA in human sweat, which provided a broad prospect for the analysis of LA in some other complicated samples.