Non-Enzymatic Glucose Detection Based on NiS Nanoclusters@NiS Nanosphere in Human Serum and Urine.

Mani Arivazhagan,Yesupatham Manova Santhosh,Govindhan Maduraiveeran

doi:10.3390/mi12040403

Mani Arivazhagan, Yesupatham Manova Santhosh + Show 1 more

Open Access

https://doi.org/10.3390/mi12040403

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Journal: Micromachines	Publication Date: Apr 5, 2021
Citations: 14	License type: CC BY 4.0

Affiliation: SRM Institute of Science and Technology

Abstract

Herein, we report a non-enzymatic electrochemical glucose sensing platform based on NiS nanoclusters dispersed on NiS nanosphere (NC-NiS@NS-NiS) in human serum and urine samples. The NC-NiS@NS-NiS are directly grown on nickel foam (NF) (NC-NiS@NS-NiS|NF) substrate by a facile, and one-step electrodeposition strategy under acidic solution. The as-developed nanostructured NC-NiS@NS-NiS|NF electrode materials successfully employ as the enzyme-mimic electrocatalysts toward the improved electrocatalytic glucose oxidation and sensitive glucose sensing. The NC-NiS@NS-NiS|NF electrode presents an outstanding electrocatalytic activity and sensing capability towards the glucose owing to the attribution of great double layer capacitance, excessive electrochemical active surface area (ECASA), and high electrochemical active sites. The present sensor delivers a limit of detection (LOD) of ~0.0083 µM with a high sensitivity of 54.6 µA mM−1 cm−2 and a wide linear concentration range (20.0 µM–5.0 mM). The NC-NiS@NS-NiS|NF-based sensor demonstrates the good selectivity against the potential interferences and shows high practicability by glucose sensing in human urine and serum samples.

Highlights

Designed electrochemical sensors and biosensors platforms have fascinated a wideranging consideration owing to their potential uses in the area of monitoring of bioprocess, management of diabetes, and biomedical applications [1,2,3]
Glucose, an imperative biomolecule that plays a dynamic role in the area of biomedical for the study of human health and physiological events [4,5]
It is recommended that diabetes patients square their blood glucose level daily at periodic conditions and take shots of periodic insulin for constant monitoring of their blood glucose levels

Summary

Introduction

Designed electrochemical sensors and biosensors platforms have fascinated a wideranging consideration owing to their potential uses in the area of monitoring of bioprocess, management of diabetes, and biomedical applications [1,2,3]. Due to the large number of increase of diabetic cases, the urgent design and development of high-performance electrochemical glucose sensors is highly required. The major clinical diagnosis and managing of disease is dependent upon the level of blood glucose concentration [6,7,8], which may be lower or higher than the normal range of concentration of glucose (~4.4 to ~6.7 mmol/L) in human blood [9,10,11].

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