Nonenzymatic electrochemical glucose biosensor constructed by NiCo2O4@Ppy nanowires on nickel foam substrate

Abstract

A rational design of multi-component composite used on glucose sensing is important for prevention and treatment of diabetes. In this report, NiCo2O4@polypyrrole nanowires (NiCo2O4@Ppy NWs) were fabricated on a nickel foam (NF) substrate via a well-designed sequential method. Benefitting from a synergy of the 3D-NF, the core of NiCo2O4 nanowires and the conductive coating of Ppy, the hybrid NF/NiCo2O4@Ppy presented a high capability for nonenzymatic electrochemical glucose sensing. The sensitivity of a sensor fabricated with the hybrid could reach as high as 3059 μA mM−1 cm−2, the detection limit could be as low as 0.22 μM (S/N = 3), and the linear range was 0.001–20 mM. In addition, it showed a good reproducibility (R.S.D. = 1.7%) and a high selectivity. The sensing electrode was also feasible in the analysis of real serum samples.