Non-enhanced, ECG-gated MR angiography of the pedal vasculature: comparison with contrast-enhanced MR angiography and digital subtraction angiography in peripheral arterial occlusive disease.

Abstract

This study was conducted in order to compare a high resolution, non-contrast-enhanced MRA (NATIVE SPACE, NE-MRA) of the pedal vasculature with contrast-enhanced MRA (CE-MRA) and digital subtraction angiography (DSA) in patients with peripheral arterial occlusive disease (PAOD). The prospective study consists of 20 PAOD patients. All patients underwent percutaneous transluminal angioplasty or stenting and received MR angiographies the following day. With CE-MRA, 75.7% of vessel segments showed good, 16.4% suboptimal and 7.9% not usable image quality. With NE-MRA, 64.6% showed good, 18.6% suboptimal and 16.8% not usable image quality. CE-MRA showed a sensitivity and negative predictive value of 90%/95% regarding significant stenosis (greater than 50%), and specificity and positive predictive value were 88%/77%. Accordingly, sensitivity and negative predictive value for the NE-MRA were 96%/97% and specificity and positive predictive value were 80%/69% for stenoses greater than 50%. The applied NE-MRA technique achieves high diagnostic accuracy even in very small distal arteries of the foot. However, the rate of non-diagnostic vessel segments is considerably higher for NE-MRA than for CE-MRA. NE-MRA is a valuable alternative to CE-MRA in selected patients. • Comparison of non-enhanced MRA with contrast-enhanced MRA and DSA as gold standard. • High resolution MRA at 3T for the depiction of small pedal vessels. • Evaluation of high resolution non-enhanced MRA in PAOD patients.