Abstract
Molecularly imprinted polymers (MIPs) are an effective method for separating enantiomeric compounds. The main objective of this research is to synthesize D-arabinitol MIPs, which can selectively separate D-arabinitol and its potential application to differentiate it from its enantiomer compound through a non-covalent approach. A macroporous polymer was synthesized using D-arabinitol as a template, acrylamide as a functional monomer, ethylene glycol dimethacrylate (EGDMA) being a cross-linker, dimethylsulfoxide (DMSO) being a porogen, as well as benzoyl peroxide being an initiator. After polymer synthesis, D-arabinitol was removed by a mixture of methanol and acetic acid (4:1, v/v). Fourier-Transform Infrared spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) distinguished the MIPs and NIPs. A selectivity test of MIPs against its enantiomers (L-arabinitol, xylitol, adonitol, and glucose) was carried out using the batch rebinding method. The binding site was quantitatively determined using the Langmuir equation. The results of the selectivity test showed that the MIPs produced was quite selective toward its enantiomer and could potentially be used to separate D-arabinitol from its enantiomer.
Highlights
D-arabinitol is a sugar alcohol with five carbon atoms which is a major metabolite of severalCandida sp
Molecularly imprinted polymers (MIPs), which has been successfully synthesized and previously reported, are carried out through a covalent approach involving the formation of a reversible weak covalent bond between the vicinal arabinitol hydroxyl group and using boron acid substituents from bithiophene functional monomers[12]
The illustration of the formation of MIPs D-arabinitol is shown in scheme 1
Summary
D-arabinitol is a sugar alcohol with five carbon atoms which is a major metabolite of severalCandida sp. Arabinitol has the potential to be used as a diagnostic tool for candidiasis patients[1,2,5,6,7]. D-arabinitol has low specificity as a diagnostic tool because of an increased level of D-. Arabinitol in the blood which has been found in candidiasis patients and in patients suffering from kidney dysfunction. D-arabinitol, L-arabinitol, xylitol, and adonitol are isomers present in urine in the form of enantiomers. They have the same molecular formula and weight, but they have different physical formulas, properties, and biological activity. To make Darabinitol function as a diagnostic tool, a specific separation method that can separate D-arabinitol from its isomers and glucose is needed
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