Abstract
Δ G XXX, Δ H XXX and Δ S XXX protonation values of cyclic- l-dipeptides containing l-histidine ( c-Gly- l-His, c- l-Ala- l-His, c- l-Val- l-His, c- l-Phe- l-His) were determined by potentiometry and calorimetry in aqueous solution at 25°C and I = 0.1 mol dm −3 (KNO 3). The thermodynamic parameters were compared with those of imidazole, determined under the same experimental conditions, to assess the role played by non-covalent interactions in the proton complex formation. In addition, a comparison with c-Gly- l-His allowed an observation to be made of the effects of side-chain residues on conformations in protonation reactions.
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