Abstract
Primary culture of cerebral cortical neurons from mouse embryo was treated with non-competitive N-methyl- d-aspartate (NMDA) receptor antagonists, FR115427 and MK801. Both FR115427 and MK801 at 1–10 μM promoted neuronal survival after 7 days cultivation, determined by calorimetric assay for acid phosphatase (AP) activity. FR 115426, the (−) isomer of FR115427 also promoted neuronal survival. However, competitive NMDA antagonists, APH and CGS19755 did not show promotive effect on neuronal survival at up to 100 μM. Anti-NMDA activity of these compounds was evaluated using an NMDA-induced convulsion assay. The relative potency of anti-NMDA activity was CGS19755 > MK801 > APH > FR115427 > FR115426. These data suggest that the effects on neuronal survival by FR115427 and MK801 are independent of anti-NMDA activity.
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