Abstract
Odontoblasts are cells that contribute to the formation of the dental pulp complex. The differentiation of dental tissue-derived mesenchymal stem cells into odontoblasts comprises many factors and signaling pathways. Noncoding RNAs (ncRNAs), comprising a substantial part of poly-A tail mature RNAs, are considered “transcriptional noise.” Emerging evidence has shown that ncRNAs have key functions in the differentiation of mesenchymal stem cells. In this review, we discussed two major types of ncRNAs, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), in terms of their role in the odontogenic differentiation of dental tissue-derived stem cells. Recent findings have demonstrated important functions for miRNAs and lncRNAs in odontogenic differentiation. It is expected that ncRNAs will become promising therapeutic targets for dentin regeneration based on stem cells.
Highlights
Mesenchymal stromal cells are derived from the mesoderm, and among these, there are stem cells [1]
The analysis indicated that there are a total of 144 long noncoding RNAs (lncRNAs) that participate in odontogenic differentiation
This study revealed that lncRNA-H19/miR-141/SPAG9 axis modulates the odontogenic differentiation of SCAPs via mitogen-activated protein kinase (MAPK) pathways
Summary
Mesenchymal stromal cells are derived from the mesoderm, and among these, there are stem cells (mesenchymal stem cells, MSCs) [1]. The results suggested that there is a positive reciprocal feedback loop in the miR-21/STAT3 signaling pathway that may enhance the process of odontogenic differentiation of human DPSCs. In 2019, Huang et al [51] showed that miR-223-3p is expressed at a higher level in inflamed pulp tissues compared with healthy tissues.
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