Abstract
Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. In parallel, a rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/pathology. In this Mini‐Review, we highlight a selection of studies in order to demonstrate the wide‐scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders. This research is opening new avenues to novel therapeutic approaches.
Highlights
Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes
myocardial infarction–associated transcript (MIAT) is found at low levels in platelets from patients with myocardial infarction [147], whereas elevated levels of this Long noncoding RNAs (lncRNAs) are found in myocardial samples from patients with dilated cardiomyopathy suffering from Chagas disease [148]
The constellations of physiological processes which orchestrate life are subject to intricate control
Summary
Noncoding RNAs are emerging as potent and multifunctional regulators in all biological processes. A rapidly growing number of studies has unravelled associations between aberrant noncoding RNA expression and human diseases. These associations have been extensively reviewed, often with the focus on a particular microRNA (miRNA) (family) or a selected disease/ pathology. In this Mini-Review, we highlight a selection of studies in order to demonstrate the wide-scale involvement of miRNAs and long noncoding RNAs in the pathophysiology of three types of diseases: cancer, cardiovascular and neurological disorders.
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