Abstract
The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.
Highlights
Diabetes is a common chronic metabolic disease which has affected about half a billion people in the world
Many studies have found that noncoding RNAs (ncRNAs) play a vital role in diabetic nephropathy glomerular podocyte injury, renal tubular epithelial cell injury, glomerular mesangial cell proliferation and fibrosis, glomerular extracellular matrix accumulation, microvascular disease, endoplasmic reticulum stress and inflammation reaction, and other pathophysiological processes [12,13,14]
We summarize the pathological roles of three types of ncRNAs in the progression of Diabetic nephropathy (DN) (Figure 1) and illustrate their diagnostic and therapeutic potential in this disease
Summary
Diabetes is a common chronic metabolic disease which has affected about half a billion people in the world. There is increasing evidence that altered noncoding RNAs (ncRNAs), especially microRNAs (miRNAs), are closely related to the occurrence and progression of DN [7,8,9,10]. Many studies have found that ncRNAs play a vital role in diabetic nephropathy glomerular podocyte injury, renal tubular epithelial cell injury, glomerular mesangial cell proliferation and fibrosis, glomerular extracellular matrix accumulation, microvascular disease, endoplasmic reticulum stress and inflammation reaction, and other pathophysiological processes [12,13,14]. We summarize the pathological roles of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN (Figure 1) and illustrate their diagnostic and therapeutic potential in this disease
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